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Antioxidant activities of Toona Sinensis leaves extracts using different antioxidant models
Ist Teil von
Food and chemical toxicology, 2008, Vol.46 (1), p.105-114
Ort / Verlag
Oxford: Elsevier Ltd
Erscheinungsjahr
2008
Quelle
MEDLINE
Beschreibungen/Notizen
The aim of the present study was to investigate the antioxidant activity of aqueous extracts of
Toona sinensis (TS; 0–100
μg/mL) and gallic acid (0–50
μg/mL), with the purified natural phenolic components evaluated using different antioxidant models. It was found that the TS extracts and gallic acid possess effective antioxidant activity against various oxidative systems
in vitro, including the scavenging of free and superoxide anion radicals, reducing power, and metal chelation. However, antioxidant activity in terms of metal chelation was not observed for the gallic acid. Moreover, TS extracts and gallic acid appear to possess powerful antioxidant properties with respect to oxidative modification of human LDL induced by CuSO4, AAPH or sodium nitroprusside, as assessed by the relative electrophoretic mobility, TBARS formation, and cholesterol degradation of oxidized LDL. Furthermore, AAPH-induced oxidative hemolysis, lipid peroxidation, and decline in superoxide dismutase (SOD) activity in human erythrocytes were prevented by both the TS extracts and the gallic acid. Our findings suggest that
T. sinensis may act as a chemopreventative agent, providing antioxidant properties and offering effective protection from atherogenesis.