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A Decade of Tissue Microarrays: Progress in the Discovery and Validation of Cancer Biomarkers
Ist Teil von
Journal of clinical oncology, 2008-12, Vol.26 (34), p.5630-5637
Ort / Verlag
Alexandria, VA: American Society of Clinical Oncology
Erscheinungsjahr
2008
Link zum Volltext
Quelle
Free E-Journal (出版社公開部分のみ）
Beschreibungen/Notizen
This year, 2008, marks the 10-year anniversary of the development of the modern tissue microarray (TMA). During the last decade, the use of TMAs has grown steadily and accounts for a small but increasing percentage of all cancer biomarker studies performed. The growing popularity of TMA-based studies attests to their benefits in the discovery and validation of new biomarkers. This review will focus on these benefits, but also on the faults of TMAs and the challenges of TMA studies that have been overcome in the last decade. We will also discuss the role of TMAs in the latest revolution in cancer treatment, the use of targeted drug therapy.