Biological and Pharmaceutical Bulletin, 2008/10/01, Vol.31(10), pp.1847-1851
2008
Details
- Autor(en) / Beteiligte
- Titel
- Free Fatty Acid Receptors and Drug Discovery
- Ist Teil von
- Biological and Pharmaceutical Bulletin, 2008/10/01, Vol.31(10), pp.1847-1851
- Ort / Verlag
- Japan: The Pharmaceutical Society of Japan
- Erscheinungsjahr
- 2008
- Link zum Volltext
- Quelle
- Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
- Beschreibungen/Notizen
- Utilizing the human genome database, the recently developed G-protein-coupled receptor (GPCR) deorphanizing strategy successfully identified multiple receptors of free fatty acids (FFAs) and is proposed to play a critical role in a variety of physiologic homeostasis mechanisms. GPR40 and GPR120 are activated by medium- and long-chain FFAs, whereas GPR41 and GPR43 are activated by short-chain FFAs. GPR40, which is preferentially expressed in pancreatic β-cells, mediates insulin secretion. On the other hand, GPR120, which is abundantly expressed in the intestine, functions as a receptor for unsaturated long-chain FFAs and promotes the secretion of glucagon-like peptide-1 (GLP-1). In this review, we summarize the identification, structure, and pharmacology of the receptors and speculate on the respective physiologic roles that FFA receptor family members may play.
- Sprache
- Englisch; Japanisch
- Identifikatoren
- ISSN: 0918-6158eISSN: 1347-5215DOI: 10.1248/bpb.31.1847Titel-ID: cdi_proquest_miscellaneous_69621829
- Format
- –
- Schlagworte
- Animals, Drug Design, Fatty Acid-Binding Proteins - drug effects, Fatty Acid-Binding Proteins - genetics, Fatty Acid-Binding Proteins - metabolism, free fatty acid, G protein coupled receptor, G protein receptor 120, G protein receptor 40, Humans, insulin, Ligands, Receptors, G-Protein-Coupled - drug effects, Receptors, G-Protein-Coupled - genetics, Receptors, G-Protein-Coupled - metabolism, Receptors, G-Protein-Coupled - physiology