Details

Autor(en) / Beteiligte

• Peterson, N
• Guthery, S
• Denson, L
• Lee, J
• Saeed, S
• Prahalad, S
• Biank, V
• Ehlert, R
• Tomer, G
• Grand, R
• Rudolph, C
• Kugathasan, S

Titel

Genetic variants in the autophagy pathway contribute to paediatric Crohn’s disease

Ist Teil von

• Gut, 2008-09, Vol.57 (9), p.1336-1337

Ort / Verlag

England: BMJ Publishing Group Ltd and British Society of Gastroenterology

Erscheinungsjahr

2008

Link zum Volltext

Quelle

BMJ Journals Archiv - DFG Nationallizenzen

Beschreibungen/Notizen

• Current study Comparison studies SNP Gene/region Cases: minor allele frequency (95% CI*) n = 555 Controls: minor allele frequency (95% CI*) n = 486 p Allele test p Genotype test OR (95% CI) Cases: minor allele frequency Controls: minor allele frequency OR (reference) rs2241880 ATG16L1 0.41 (0.38 to 0.44) 0.48 (0.45 to 0.52) 0.001 0.007 0.74 (0.62 to 0.89) 0.353 0.478 0.68 4 rs11209026 IL23R 0.03 (0.02 to 0.04) 0.06 (0.04 to 0.07) 0.001 0.001 0.49 (0.31 to 0.77) 0.025 0.07 0.34 2 rs224136 Intergenic 0.14 (0.12 to 0.16) 0.18 (0.15 to 0.2) 0.014 0.05 0.74 (0.58 to 0.94) 0.14 0.23 0.6 4 rs8050910 FAM92B 0.43 (0.4 to 0.46) 0.45 (0.42 to 0.48) 0.365 0.558 0.92 (0.77 to 1.10) 0.4 0.43 0.84 4 rs16853571 PHOX2B 0.06 (0.05 to 0.08) 0.06 (0.04 to 0.07) 0.584 0.162 0.90 (0.63 to 1.30) 0.057 0.047 0.69 rs13361189 IRGM 0.11 (0.09 to 0.13) 0.08 (0.06 to 0.1) 0.036 0.113 1.38 (1.02 to 1.87) 0.108 0.081 1.38 3 rs10883365 NKX2-3 0.52 (0.49 to 0.55) 0.48 (0.45 to 0.51) 0.05 0.148 1.19 (1.00 to 1.41) 0.523 0.482 1.18 3 rs9858542 Chr 3p21 0.33 (0.3 to 0.36) 0.3 (0.27 to 0.33) 0.123 0.013 1.16 (0.96 to 1.40) 0.324 0.291 1.17 3 rs4958847 IRGM 0.14 (0.12 to 0.16) 0.12 (0.1 to 0.14) 0.166 0.376 1.21 (0.92 to 1.57) 0.158 0.125 1.36 3 rs2542151 PTPN2 0.17 (0.15 to 0.19) 0.16 (0.13 to 0.18) 0.344 0.119 1.12 (0.88 to 1.42) 0.196 0.175 1.15 3 Rs1793004 NELL1 0.23 (0.21 to 0.26) 0.25 (0.22 to 0.28) 0.375 0.217 0.91 (0.76 to 1.12) 0.23 0.27 0.77 5 Values in bold are statistically significant. *Confidence intervals estimated from 100 000 bootstrap replicates.