Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Folate Metabolism Polymorphisms Influence Risk of Colorectal Adenoma Recurrence
Ist Teil von
Cancer epidemiology, biomarkers & prevention, 2006-09, Vol.15 (9), p.1607-1613
Ort / Verlag
Philadelphia, PA: American Association for Cancer Research
Erscheinungsjahr
2006
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Folate intake is inversely related to risk of developing colorectal neoplasia. Associations between risk of colorectal neoplasia
and polymorphisms in genes coding for enzymes involved in folate metabolism have also been reported, suggesting a relationship
between genotype and development of colorectal neoplasia. To further investigate the effects of folate metabolism genotypes
on colorectal neoplasia, we genotyped 546 patients participating in a randomized controlled trial of folate supplementation
for the prevention of colorectal adenoma recurrence. A significantly reduced risk of recurrence was observed in patients heterozygous
for the MTRR A66G polymorphism [relative risk (RR), 0.64; 95% confidence interval (95% CI), 0.46-0.90] or heterozygous for the MTHFR A1298C polymorphism (RR, 0.71; 95% CI, 0.52-0.97). Furthermore, a significant reduction in recurrence risk was seen in MTRR A66G heterozygotes who received folate supplements but not in those who did not receive folate. Patients heterozygous for
the MTHFR C677T polymorphism had a nonsignificant risk reduction (RR, 0.92; 95% CI, 0.69-1.23), as did patients with one or two variant
alleles for the MTR A2756G polymorphism (RR, 0.82; 95% CI, 0.60-1.12). No influence on recurrence risk was observed for the TSER, TSER 3R G>C, and TS 1494del6 variants. These findings provide additional support for the hypothesis that germ line variants in folate metabolism
genes influence the development of colorectal adenomas. (Cancer Epidemiol Biomarkers Prev 2006;15(9):1607–13)