Details

Autor(en) / Beteiligte

• Girod, Angélique
• Roger, Thierry
• Breton, Pierre
• Bouletreau, Pierre

Titel

Experimental study of mineralization in mandibular bone distraction with irradiation during the consolidation phase

Ist Teil von

• Journal of cranio-maxillo-facial surgery, 2005-12, Vol.33 (6), p.386-394

Ort / Verlag

Kidlington: Elsevier Ltd

Erscheinungsjahr

2005

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• This study aimed at assessing the effect of radiotherapy on regenerated bone mineralization and consolidation obtained by mandibular bone distraction. The planned application was a new immediate mandibular reconstruction technique in defects following surgery for oral cavity tumours requiring postoperative radiotherapy. Ten sheep underwent bilateral mandibular bone distraction (control group). A second group of 6 sheep (study group) had bilateral mandibular bone distraction followed by irradiation on the 21st postoperative day. The animals were sacrificed on the 60th postoperative day. Radiographic and histomorphometric studies were performed. In the control group, 9 distraction sites out of 20 were consolidated. In the irradiated group, 9 out of 12 were consolidated. Histomorphometric analysis did not demonstrate any statistically significant difference between the osseous and cartilaginous samples, the trabecular thickness of the new bone, or the osteoid surface of basal bone in the control and test groups ( p = 0.126 , 0.247 , 0.792 , 0.082 ). However, the osteoid surface of the regenerated bone in the test group was statistically smaller ( p = 0.017 ) than in the control group. In this experiment, radiotherapy did not hinder bone mineralization or consolidation following distraction of mandibular bone receiving irradiation on the 21st postoperative day. Bone distraction could be proposed for the repair of mandibular defects following surgery for oral tumours which require early postoperative radiotherapy.