Details

Autor(en) / Beteiligte

• Kidd, Elizabeth A.
• Siegel, Barry A.
• Dehdashti, Farrokh
• Grigsby, Perry W.

Titel

The standardized uptake value for F‐18 fluorodeoxyglucose is a sensitive predictive biomarker for cervical cancer treatment response and survival

Ist Teil von

• Cancer, 2007-10, Vol.110 (8), p.1738-1744

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2007

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• BACKGROUND. The objective of this study was to evaluate cervical tumor uptake of F‐18 fluorodeoxyglucose (FDG) measured as the maximal standardized uptake value (SUVmax) by positron emission tomography (PET) and its association with treatment response and prognosis in patients with cervical cancer. METHODS. The study population consisted of 287 patients with stage IA2 through IVB cervical cancer who underwent pretreatment FDG‐PET studies. SUVmax, tumor volume, and sites of lymph node metastasis were recorded. Therapy included surgery, chemoradiation, or palliation. RESULTS. The mean SUVmax was 11.4 (range, 1–50.4). The mean tumor volume by stage was 42.1 cm3 for stage I tumors (using International Federation of Gynecology and Obstetrics [FIGO] staging criteria), 63.7 cm3 for stage II tumors, 129.2 cm3 for stage III tumors, and 166.2 cm3 for stage IV tumors. There was no correlation between tumor volume and SUVmax (correlation coefficient [R2] = 0.01). No significant difference in SUVmax was observed between squamous histology (n = 247 patients) and nonsquamous histology (n = 40 patients; P = .089). Higher SUVmax was associated with an increased risk of lymph node metastasis at diagnosis (P = .0009). A Cox proportional‐hazards model for death from cervical cancer was used to evaluate tumor histology, lymph node metastasis, tumor volume, and SUVmax. The results indicated that SUVmax was the only significant independent factor (P = .0027). Three prognostic groups were established using SUVmax. The overall survival rates at 5 years were 95% for an SUVmax ≤ 5.2, 70% for an SUVmax > 5.2 and ≤13.3, and 44% for an SUVmax > 13.3 (P < .0001). Increasing SUVmax was associated with persistent abnormal FDG uptake in the cervix on 3‐month FDG‐PET studies in 238 patients who received curative chemoradiation (P = .04). CONCLUSIONS. The SUVmax of the cervical tumor at diagnosis was a sensitive biomarker of treatment response and prognosis for patients with cervical cancer. Cancer 2007. © 2007 American Cancer Society. The maximal standardized uptake value (SUVmax) of the cervical tumor at diagnosis is a sensitive biomarker of treatment response and prognosis for patients with cervical cancer. In this study of 287 patients with stage IA2 through IVB cervical cancer, increasing SUVmax was associated with persistent, abnormal F‐18 fluorodeoxyglucose (FDG) uptake in the cervix on 3‐month FDG‐positron emission tomography studies.