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Cu(II)-Catalyzed Functionalizations of Aryl C−H Bonds Using O2 as an Oxidant
Ist Teil von
Journal of the American Chemical Society, 2006-05, Vol.128 (21), p.6790-6791
Ort / Verlag
Washington, DC: American Chemical Society
Erscheinungsjahr
2006
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Cu(II)-catalyzed acetoxylation and halogenation of aryl C−H bonds are developed. ortho-Selectivity was observed with a wide range of 2-arylpyridine substrates. Both mono- and difunctionalizations are achieved by tuning the reaction conditions. Excellent functional group tolerance and use of O2 as a stoichiometric oxidant are significant advantages over our recently developed Pd-catalyzed C−H functionalization reactions. These newly discovered reaction conditions are also applicable for cyanation, amination, etherification, and thioetherification of aryl C−H bonds. Mechanistic investigations are carried out to gain insights into the Cu(II)-catalyzed C−H functionalization reactions.