Details

Autor(en) / Beteiligte

• Bradshaw, Catriona S.
• Morton, Anna N.
• Hocking, Jane
• Garland, Suzanne M.
• Morris, Margaret B.
• Moss, Lorna M.
• Horvath, Leonie B.
• Kuzevska, Irene
• Fairley, Christopher K.

Titel

High Recurrence Rates of Bacterial Vaginosis over the Course of 12 Months after Oral Metronidazole Therapy and Factors Associated with Recurrence

Ist Teil von

• The Journal of infectious diseases, 2006-06, Vol.193 (11), p.1478-1486

Ort / Verlag

United States: The University of Chicago Press

Erscheinungsjahr

2006

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• BackgroundWe wished to determine recurrences of bacterial vaginosis (BV) after treatment over the course of 12 months and to establish factors associated with recurrence MethodsWomen with symptomatic BV (a Nugent score [NS] of 7–10 or of 4–6 with ⩾3 Amsel criteria) were enrolled. BV was treated with 400 mg of oral metronidazole twice a day for 7 days. Participants completed a questionnaire and vaginal swabs were collected at 1, 3, 6, and 12 months; the study end point was an NS of 7–10 ResultsA total of 121 (87%) women with an NS of 7–10 and 18 (13%) with an NS of 4–6 and ⩾3 Amsel criteria were enrolled; 130 (94%) returned ⩾1 vaginal samples. Sixty-eight women (58% [95% confidence interval {CI}, 49%–66%]) had a recurrence of BV (NS 7–10), and 84 (69% [95% CI, 61%–77%]) had a recurrence of abnormal vaginal flora (NS 4–10) by 12 months. A past history of BV, a regular sex partner throughout the study, and female sex partners were significantly associated with recurrence of BV and abnormal vaginal flora by multivariate analysis; the use of hormonal contraception had a negative association with recurrence ConclusionCurrent recommended treatment is not preventing the recurrence of BV or abnormal vaginal flora in the majority of women; factors associated with recurrence support a possible role for sexual transmission in the pathogenesis of recurrent BV