Science (American Association for the Advancement of Science), 1996-03, Vol.271 (5254), p.1406-1409
1996
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)
- Ist Teil von
- Science (American Association for the Advancement of Science), 1996-03, Vol.271 (5254), p.1406-1409
- Ort / Verlag
- Washington, DC: American Society for the Advancement of Science
- Erscheinungsjahr
- 1996
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- The transition metal ion copper(II) has a critical role in chronic neurologic diseases. The amyloid precursor protein (APP) of Alzheimer's disease or a synthetic peptide representing its copper-binding site reduced bound copper(II) to copper(I). This copper ion-mediated redox reaction led to disulfide bond formation in APP, which indicated that free sulfhydryl groups of APP were involved. Neither superoxide nor hydrogen peroxide had an effect on the kinetics of copper(II) reduction. The reduction of copper(II) to copper(I) by APP involves an electron-transfer reaction and could enhance the production of hydroxyl radicals, which could then attack nearby sites. Thus, copper-mediated toxicity may contribute to neurodegeneration in Alzheimer's disease.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.271.5254.1406Titel-ID: cdi_proquest_miscellaneous_36297576
- Format
- –
- Schlagworte
- Alzheimer Disease - metabolism, Alzheimer's disease, Alzheimers disease, Amyloid beta-Protein Precursor - antagonists & inhibitors, Amyloid beta-Protein Precursor - chemistry, Amyloid beta-Protein Precursor - metabolism, Amyloids, Binding Sites, Biological and medical sciences, Copper, Copper - metabolism, Cysteine - chemistry, Cystine - metabolism, Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases, Dimers, Disulfides, Electron Transport, Ferric Compounds - metabolism, Free radicals, Histidine - chemistry, Humans, Hydrogen Peroxide - metabolism, Hydroxyl Radical - metabolism, Mass Spectrometry, Mass spectroscopy, Medical sciences, Molecules, Neurology, Neurons, Neuroscience, Oligopeptides - pharmacology, Oxidation-Reduction, Peptide Fragments - chemistry, Peptide Fragments - metabolism, Peptides, Peroxides, Proteins, Recombinant Fusion Proteins - metabolism, Scientific Concepts, Superoxides - metabolism