Details

Autor(en) / Beteiligte

• Genet, Sylvia A.A.M.
• Visser, Esther
• Youssef-El Soud, Maggy
• Belderbos, Huub N.A.
• Stege, Gerben
• de Saegher, Marleen E.A.
• Westeinde, Susan C. van 't
• Brunsveld, Luc
• Broeren, Maarten A.C.
• van de Kerkhof, Daan
• Eduati, Federica
• van den Borne, Ben E.E.M.
• Scharnhorst, Volkher

Titel

Strengths and challenges in current lung cancer care: Timeliness and diagnostic procedures in six Dutch hospitals

Ist Teil von

• Lung cancer (Amsterdam, Netherlands), 2024-03, Vol.189, p.107477-107477, Article 107477

Ort / Verlag

Ireland: Elsevier B.V

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •Timeliness of LC care significantly differs between types of LC.•More invasive diagnostic procedures are performed for early stage NSCLC.•Some LC patients receive extra invasive procedures only for molecular diagnostics.•Improvements regarding timely and less invasive LC care should be made. Timely diagnosis of lung cancer (LC) is crucial to achieve optimal patient care and outcome. Moreover, the number of procedures required to obtain a definitive diagnosis can have a large influence on the life expectancy of a patient. Here, adherence with existing Dutch guidelines for timeliness and type and number of invasive and imaging procedures was assessed. 1096 patients with suspected LC were enrolled in this multicenter prospective study (NL9146). The overall survival, time from referral to the first appointment with the pulmonologist, time to diagnosis and treatment, and the number of imaging and invasive procedures were evaluated. Patients were divided into different diagnostic groupsearly- and advanced stage non-small-cell lung cancer (NSCLC), small-cell lung cancer (SCLC), large cell neuroendocrine carcinoma of the lung (LCNEC), patients without LC and patients without a definitive diagnosis. The majority of patients (66 %) received a definitive diagnosis within 5 weeks, although the time to diagnosis of early-stage LC patients and patients without LC was significantly longer comparted to advanced stage LC. An increase in invasive procedures was seen for early-stage LC compared to advanced stage LC and for 13 % of the advanced stage non-squamous NSCLC patients up to three additional invasive procedures were performed solely to obtain sufficient material for NGS. For patients without a definitive diagnosis, 50 % did undergo at least one invasive procedure, while 11 % did not wish to undergo any invasive procedures. These insights could aid in improved LC diagnostics and efficient implementation of new techniques like liquid biopsy and artificial intelligence. This may lead to more timely LC care, a decreased number of invasive procedures, less variability between the diagnostic trajectory of different patients and aid in obtaining a definitive diagnosis for all patients.