Details

Autor(en) / Beteiligte

• Rozman, Jan
• Yeomans, Julia M
• Sknepnek, Rastko

Titel

Shape-Tension Coupling Produces Nematic Order in an Epithelium Vertex Model

Ist Teil von

• Physical review letters, 2023-12, Vol.131 (22), p.228301-228301, Article 228301

Ort / Verlag

United States

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• We study the vertex model for epithelial tissue mechanics extended to include coupling between the cell shapes and tensions in cell-cell junctions. This coupling represents an active force which drives the system out of equilibrium and leads to the formation of nematic order interspersed with prominent, long-lived +1 defects. The defects in the nematic ordering are coupled to the shape of the cell tiling, affecting cell areas and coordinations. This intricate interplay between cell shape, size, and coordination provides a possible mechanism by which tissues could spontaneously develop long-range polarity through local mechanical forces without resorting to long-range chemical patterning.