Details

Autor(en) / Beteiligte

• Cai, Wang-Yu
• Luo, Xi
• Ma, Hong-Li
• Shao, Xiao-Guang
• Wu, Xiao-Ke

Titel

Association between preconception serum lipid concentrations and treatment outcomes in women with PCOS who underwent ovulation induction

Ist Teil von

• Reproductive biomedicine online, 2022-10, Vol.45 (4), p.805-814

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• What is the association between preconception serum lipid concentrations and reproductive outcomes after ovulation induction in women with polycystic ovary syndrome (PCOS)? A secondary analysis of a randomized controlled trial with 1000 PCOS women undergoing ovulation induction with clomiphene with or without acupuncture. Preconception serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB) were measured. Outcomes were ovulation, conception, pregnancy, live birth and miscarriage. Logistic regression was used to calculate odds ratios (OR) with 95% confidence intervals (CI). In total, 780 women ovulated; 320 women achieved conception, 218 had a clinical pregnancy, 205 had a live birth and 115 had a miscarriage. Serum lipid concentrations per one unit increment were independently associated with reproductive outcomes after controlling for confounders. Increasing LDL-C (OR 0.79, 95% CI 0.63–0.99) was independently associated with a lower chance of ovulation. Increasing total cholesterol (OR 0.76, 95% CI 0.62–0.92), LDL-C (OR 0.73, 95% CI 0.57–0.93), triglycerides (OR 0.74, 95% CI 0.58–0.95) and ApoB (OR 0.34, 95% CI 0.16–0.74) were independently associated with a lower chance of clinical pregnancy. Increased total cholesterol (OR 0.78, 95% CI 0.64–0.96), LDL-C (OR 0.77, 95% CI 0.60–0.99), triglycerides (OR 0.76, 95% CI 0.59–0.96) and ApoB (OR 0.39, 95% CI 0.18–0.86) were independently associated with a lower chance of live birth. Furthermore, increased total cholesterol (OR 1.43, 95% CI 1.06–1.93), LDL-C (OR 1.51, 95% CI 1.04–2.19) and ApoB (OR 3.82, 95% CI 1.17–12.41) were independently associated with a higher chance of miscarriage. Increased serum lipids were negatively associated with the reproductive outcomes of PCOS women undergoing ovulation induction with clomiphene with or without acupuncture.