Details

Autor(en) / Beteiligte

• Scuto, M.
• Modafferi, S.
• Rampulla, F.
• Zimbone, V.
• Tomasello, M.
• Spano’, S.
• Ontario, M.L.
• Palmeri, A.
• Trovato Salinaro, A.
• Siracusa, R.
• Di Paola, R.
• Cuzzocrea, S.
• Calabrese, E.J.
• Wenzel, U.
• Calabrese, V.

Titel

Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy

Ist Teil von

• Mechanisms of ageing and development, 2022-07, Vol.205, p.111686-111686, Article 111686

Ort / Verlag

Ireland: Elsevier B.V

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Recent evidence demonstrates that Crocus sativus L. (saffron) counteracts oxidative stress, mitochondrial dysfunction and neuroinflammation, closely linked to initiation and progression of major brain pathologies. Interestingly, saffron constituents such as crocin, crocetin and safranal can exert antioxidant or toxic effects depending on their endogenous concentration. According to the hormesis principles, at low dose they act as antioxidants in a wide range of brain diseases by upregulating Nrf2 signaling pathway and the expression of vitagenes, such as NAD(P)H-quinone oxidoreductase (NQO1), glutathione transferase (GT), heme oxygenase-1 (HO-1), sirtuin-1 (Sirt1) and thioredoxin (Trx) system. Importantly, neuronal dysregulation of Nrf2 pathway can be a prominent cause of selective susceptibility, under neuroinflammatory conditions, due to the high vulnerability of brain cells to oxidative stress. Here we discuss natural inducers from saffron targeting Nrf2/vitagene pathway for development of new therapeutical strategies to suppress oxidative stress and neuroinflammation and consequently cognitive dysfunction. In this review we also focus on the hormetic effect of saffron active constituents, summarizing their neuroprotective and anti-neuroinflammatory properties, as well as pharmacological perspectives in brain disorders. •Saffron and its active constituents exert anti-inflammatory and antioxidants effects acting via transcription of vitagenes.•Saffron preparations are promising agents for therapeutic applications in the treatment of neurodegenerative disorders.•The dose-response pattern of saffron within a hormetic response is able to modulate oxidative stress.