Details

Autor(en) / Beteiligte

• Ramadoss, Boobalan
• Jin, Yushu
• Asako, Sobi
• Ilies, Laurean

Titel

Remote steric control for undirected meta -selective C-H activation of arenes

Ist Teil von

• Science (American Association for the Advancement of Science), 2022-02, Vol.375 (6581), p.658-663

Ort / Verlag

United States: The American Association for the Advancement of Science

Erscheinungsjahr

2022

Link zum Volltext

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• Regioselective functionalization of arenes remains a challenging problem in organic synthesis. Steric interactions are often used to block sites adjacent to a given substituent, but they do not distinguish the remaining remote sites. We report a strategy based on remote steric control, whereby a roof-like ligand protects the distant site in addition to the sites, and thereby enables selective activation of carbon-hydrogen (C-H) bonds in the absence of or substituents. We demonstrate this concept for iridium-catalyzed -selective borylation of various monosubstituted arenes, including complex drug molecules. This strategy has the potential to expand the toolbox of C-H bond functionalization to previously nondifferentiable reaction sites.