Details

Autor(en) / Beteiligte

• Nguyen, Tien Ngoc‐Thuy
• Do, Thien Bui‐Thuan
• Ho, Minh Hieu
• Tran, Nam Minh‐Phuong
• Dang, Nhi Ngoc‐Thao
• Do, Thai Minh
• Nguyen, Hoai Thi‐Thu
• Phan, Thang Bach
• Tran, Quyen Ngoc
• Van Vo, Toi
• Nguyen, Hiep Thi

Titel

Investigating the effect of multi‐coated hydrogel layer on characteristics of electrospun PCL membrane coated with gelatin/silver nanoparticles for wound dressing application

Ist Teil von

• Journal of biomedical materials research. Part A, 2021-12, Vol.109 (12), p.2414-2424

Ort / Verlag

Hoboken, USA: John Wiley & Sons, Inc

Erscheinungsjahr

2021

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• In this study, the effect of coated hydrogel layer on characteristics of the whole gelatin/silver nanoparticles multi‐coated polycaprolactone membrane (PCLGelAg) was investigated through systematic and typical wound dressing characterizations to select the optimal number of layers for practical applications. Scanning electron microscopy, free swell absorptive capacity and tensile test in both wet and dry conditions were conducted to characterize all fabricated membranes of six coating times. In vitro cytotoxicity and agar diffusion evaluation were also carried out to assess the biocompatibility and antibacterial activity of the membranes. The findings illustrated that as the coated layers increase, the absorptive capacity, and degradation rate were higher, the membranes were stiffer in dry state while the tensile strength in wet state, elongation, and cell viability were significantly decreased. PCLGelAg3 was chosen to be the best fit for wound healing since it maintained quite sufficient maximum buffer uptake, elasticity, cell viability along with inducing abnormalities in bacterial morphology and preventing biofilm formation.