Details

Autor(en) / Beteiligte

• Mehta, Roopa
• Martagon, Alexandro J.
• Galan Ramirez, Gabriela A.
• Antonio-Villa, Neftali Eduardo
• Vargas-Vázquez, Arsenio
• Elias-Lopez, Daniel
• Gonzalez-Retana, Gustavo
• Rodríguez-Encinas, Bethsabel
• Ceballos-Macías, Jose J.
• Romero-Zazueta, Alejandro
• Martinez-Alvarado, Rocio
• Morales-Portano, Julieta D.
• Alvarez-Lopez, Humberto
• Sauque-Reyna, Leobardo
• Gomez-Herrera, Laura G.
• Simental-Mendia, Luis E.
• Garcia-Aguilar, Humberto
• Ramirez-Cooremans, Elizabeth
• Peña-Aparicio, Berenice
• Mendoza-Zubieta, Victoria
• Carrillo-Gonzalez, Perla A.
• Ferreira-Hermosillo, Aldo
• Caracas-Portilla, Nacu
• Jimenez-Dominguez, Guadalupe
• Ruiz-Garcia, Alinna Y.
• Arriaga-Cazares, Hector E.
• Gonzalez-Gonzalez, Jesus R.
• Mendez-Valencia, Carla V.
• Padilla, Francisco G.
• Madriz-Prado, Ramon
• De los Rios-Ibarra, Manuel O.
• Vazquez-Cardenas, Alejandra
• Arjona-Villicaña, Ruy D.
• Acevedo-Rivera, Karina J.
• Allende-Carrera, Ricardo
• Alvarez, Jose A.
• Amezcua-Martinez, Jose C.
• de los Reyes Barrera-Bustillo, Manuel
• Carazo-Vargas, Gonzalo
• Contreras-Chacon, Roberto
• Figueroa-Andrade, Mario H.
• Flores-Ortega, Ashanty
• Garcia-Alcala, Hector
• Garcia de Leon, Laura E.
• Garcia-Guzman, Berenice
• Garduño-Garcia, Jose J.
• Garnica-Cuellar, Juan C.
• Gomez-Cruz, Jose R.
• Hernandez-Garcia, Anell
• Holguin-Almada, Jesus R.
• Juarez-Herrera, Ursulo
• Lugo-Sobrevilla, Fabiola
• Marquez-Rodriguez, Eduardo
• Martinez-Sibaja, Cristina
• Medrano-Rodriguez, Alma B.
• Morales-Oyervides, Jose C.
• Perez-Vazquez, Daniel I.
• Reyes-Rodriguez, Eduardo A.
• Robles-Osorio, Ma. Ludivina
• Rosas-Saucedo, Juan
• Torres-Tamayo, Margarita
• Valdez-Talavera, Luis A.
• Vera-Arroyo, Luis E.
• Zepeda-Carrillo, Eloy A.
• Aguilar-Salinas, Carlos A.

Titel

Familial hypercholesterolemia in Mexico: Initial insights from the national registry

Ist Teil von

• Journal of clinical lipidology, 2021-01, Vol.15 (1), p.124-133

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Familial hypercholesterolemia (FH) remains underdiagnosed and undertreated. Report the results of the first years (2017-2019) of the Mexican FH registry. There are 60 investigators, representing 28 federal states, participating in the registry. The variables included are in accordance with the European Atherosclerosis Society (EAS) FH recommendations. To date, 709 patients have been registered, only 336 patients with complete data fields are presented. The mean age is 50 (36-62) years and the average time since diagnosis is 4 (IQR: 2-16) years. Genetic testing is recorded in 26.9%. Tendon xanthomas are present in 43.2%. The prevalence of type 2 diabetes is 11.3% and that of premature CAD is 9.8%. Index cases, male gender, hypertension and smoking were associated with premature CAD. The median lipoprotein (a) level is 30.5 (IQR 10.8-80.7) mg/dl. Statins and co-administration with ezetimibe were recorded in 88.1% and 35.7% respectively. A combined treatment target (50% reduction in LDL-C and an LDL-C <100 mg/dl) was achieved by 13.7%. Associated factors were index case (OR 3.6, 95%CI 1.69-8.73, P = .002), combination therapy (OR 2.4, 95%CI 1.23-4.90, P = .011), type 2 diabetes (OR 2.8, 95%CI 1.03-7.59, P = .036) and age (OR 1.023, 95%CI 1.01-1.05, P = .033). The results confirm late diagnosis, a lower than expected prevalence and risk of ASCVD, a higher than expected prevalence of type 2 diabetes and undertreatment, with relatively few patients reaching goals. Recommendations include, the use of combination lipid lowering therapy, control of comorbid conditions and more frequent genetic testing in the future. •Familial hypercholesterolemia remains underdiagnosed and undertreated in Mexico.•We present the results of the Mexican Familial Hypercholesterolemia Registry.•Over 60 investigators in 28 federal states participated in the registry.•We discuss the findings and challenges to overcome in this population.