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Details

Autor(en) / Beteiligte
Titel
A core outcome set for future endometriosis research: an international consensus development study
Ist Teil von
  • BJOG : an international journal of obstetrics and gynaecology, 2020-07, Vol.127 (8), p.967-974
Ort / Verlag
England: Wiley Subscription Services, Inc
Erscheinungsjahr
2020
Link zum Volltext
Quelle
Wiley Online Library
Beschreibungen/Notizen
  • Objective To develop a core outcome set for endometriosis. Design Consensus development study. Setting International. Population One hundred and sixteen healthcare professionals, 31 researchers and 206 patient representatives. Methods Modified Delphi method and modified nominal group technique. Results The final core outcome set includes three core outcomes for trials evaluating potential treatments for pain and other symptoms associated with endometriosis: overall pain; improvement in the most troublesome symptom; and quality of life. In addition, eight core outcomes for trials evaluating potential treatments for infertility associated with endometriosis were identified: viable intrauterine pregnancy confirmed by ultrasound; pregnancy loss, including ectopic pregnancy, miscarriage, stillbirth and termination of pregnancy; live birth; time to pregnancy leading to live birth; gestational age at delivery; birthweight; neonatal mortality; and major congenital abnormalities. Two core outcomes applicable to all trials were also identified: adverse events and patient satisfaction with treatment. Conclusions Using robust consensus science methods, healthcare professionals, researchers and women with endometriosis have developed a core outcome set to standardise outcome selection, collection and reporting across future randomised controlled trials and systematic reviews evaluating potential treatments for endometriosis. Tweetable @coreoutcomes for future #endometriosis research have been developed @jamesmnduffy. Tweetable @coreoutcomes for future #endometriosis research have been developed @jamesmnduffy. This paper includes Author Insights, a video available at https://vimeo.com/rcog/authorinsights16157

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