Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Biological tumor markers (maspin, CD105, nm23‐H1) and disease relapse in laryngeal cancer: cluster analysis
Ist Teil von
Head & neck, 2020-08, Vol.42 (8), p.2129-2136
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2020
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Background
The aim of this investigation was to see if a panel of biomarkers (maspin, CD105, and nm23‐H1) could be used to stratify patients with laryngeal squamous cell carcinoma (LSCC) in homogeneous disease recurrence risk clusters.
Methods
Cluster analysis was used to classify 89 patients based on their immunohistochemical expression of nm23‐H1, CD105, and maspin.
Results
Our analysis identified seven homogeneous clusters: the LSCC recurrence rate was lowest in cluster 6 (non‐nuclear maspin pattern, nuclear nm23‐H1 expression ≥10%, endothelial CD105 expression <6%; P = .009), and highest in cluster 3 (non‐nuclear maspin pattern, nuclear nm23‐H1 expression <10%, endothelial CD105 expression ≥6%; P <.001).
Conclusions
Similar panels of biological variables identified by cluster analysis should be tested in prospective clinical trials to establish whether treating patients identified as being at higher risk of LSCC recurrence more aggressively could significantly improve their recurrence rate and/or disease‐specific survival.