Details

Autor(en) / Beteiligte

• Fan, Pei
• Lan, Yun
• Zhang, Chang
• Wang, Chuan

Titel

Nickel/Photo-Cocatalyzed Asymmetric Acyl-Carbamoylation of Alkenes

Ist Teil von

• Journal of the American Chemical Society, 2020-02, Vol.142 (5), p.2180-2186

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• An unprecedented asymmetric acyl-carbamoylation of pendant alkenes tethered on aryl carbamic chlorides with both aliphatic and aromatic aldehydes has been developed via the cooperative catalysis of a chiral nickel-PHOX complex and tetrabutylammonium decatungstate. This reaction represents the first example of merging hydrogen-atom-transfer photochemistry and asymmetric transition metal catalysis in difunctionalization of alkenes. Using this protocol, a variety of oxindoles bearing a challenging quaternary stereogenic center are furnished under mild conditions in highly enantioselective manner.