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The Progressive Supranuclear Palsy Clinical Deficits Scale
Movement disorders, 2020-04, Vol.35 (4), p.650-661
Piot, Ines
Schweyer, Kerstin
Respondek, Gesine
Stamelou, Maria
Sckopke, Philipp
Schenk, Thomas
Goetz, Christopher G.
Stebbins, Glenn T.
Höglinger, Günter U.
Gasser, Thomas
Hermann, Andreas
Höglinger, Günter
Höllerhage, Matthias
Kimmich, Okka
Klockgether, Thomas
Levin, Johannes
Machetanz, Gerrit
Osterrath, Antje
Palleis, Carla
Prudlo, Johannes
Spottke, Annika
Berg, Daniela
Bürk, Katrin
Claßen, Joseph
Eggers, Carsten
Greuel, Andrea
Grimm, Max‐Joseph
Hermann, Lennard
Iankova, Vassilena
Jahn, Klaus
Jost, Wolfgang
Klietz, Martin
Kühn, Andrea
Marxreiter, Franz
Paschen, Steffen
Poetter‐Nerger, Monika
Preisl, Marie‐Therese
Prilop, Lisa
Tönges, Lars
Trenkwalder, Claudia
Warnecke, Tobias
Wegner, Florian
Winkler, Jürgen
Antonini, Angelo
P, Kailash P.
L, Adam L.
Colosimo, Carlo
Compta, Yaroslau
Corvol, Jean‐Christophe
I, Lawrence I.
E, Anthony E.
Litvan, Irene
R, Huw R.
Nilsson, Christer
Pantelyat, Alexander
2020
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Piot, Ines
Schweyer, Kerstin
Respondek, Gesine
Stamelou, Maria
Sckopke, Philipp
Schenk, Thomas
Goetz, Christopher G.
Stebbins, Glenn T.
Höglinger, Günter U.
Gasser, Thomas
Hermann, Andreas
Höglinger, Günter
Höllerhage, Matthias
Kimmich, Okka
Klockgether, Thomas
Levin, Johannes
Machetanz, Gerrit
Osterrath, Antje
Palleis, Carla
Prudlo, Johannes
Spottke, Annika
Berg, Daniela
Bürk, Katrin
Claßen, Joseph
Eggers, Carsten
Greuel, Andrea
Grimm, Max‐Joseph
Hermann, Lennard
Iankova, Vassilena
Jahn, Klaus
Jost, Wolfgang
Klietz, Martin
Kühn, Andrea
Marxreiter, Franz
Paschen, Steffen
Poetter‐Nerger, Monika
Preisl, Marie‐Therese
Prilop, Lisa
Tönges, Lars
Trenkwalder, Claudia
Warnecke, Tobias
Wegner, Florian
Winkler, Jürgen
Antonini, Angelo
P, Kailash P.
L, Adam L.
Colosimo, Carlo
Compta, Yaroslau
Corvol, Jean‐Christophe
I, Lawrence I.
E, Anthony E.
Litvan, Irene
R, Huw R.
Nilsson, Christer
Pantelyat, Alexander
Titel
The Progressive Supranuclear Palsy Clinical Deficits Scale
Ist Teil von
Movement disorders, 2020-04, Vol.35 (4), p.650-661
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2020
Quelle
MEDLINE
Beschreibungen/Notizen
Background There is currently no undisputed, validated, clinically meaningful measure for deficits in the broad spectrum of PSP phenotypes. Objective To develop a scale to monitor clinical deficits in patients with PSP across its broad phenotypes. Methods The Progressive Supranuclear Palsy Clinical Deficits Scale was conceptualized to cover seven clinical domains (Akinesia‐rigidity, Bradyphrenia, Communication, Dysphagia, Eye movements, Finger dexterity, and Gait & balance), each scored from 0 to 3 (no, mild, moderate, or severe deficits). User guidelines were developed to standardize its application. Progressive Supranuclear Palsy Clinical Deficits Scale scores were collected in patients fulfilling the MDS‐PSP diagnostic criteria in two independent, multicenter, observational studies, both cross‐sectionally (exploratory DescribePSP cohort; confirmatory ProPSP cohort) and longitudinally (12‐months’ follow‐up, both cohorts). Results Cognitive pretesting demonstrated easy scale utility. In total, 164 patients were scored (70.4 ± 7.6 years; 62% males, 35% variant phenotypes). Mean Progressive Supranuclear Palsy Clinical Deficits Scale completion time was 4 minutes. The Progressive Supranuclear Palsy Clinical Deficits Scale total score correlated with existing scales (e.g., Progressive Supranuclear Palsy Rating Scale: R = 0.88; P < 0.001). Individual Progressive Supranuclear Palsy Clinical Deficits Scale items correlated well with similar constructs in existing scales. Internal consistency (Cronbach's alpha: 0.75), inter‐rater reliability (0.96), and test‐retest stability (0.99) were acceptable. The PSP‐CDS showed significant 12‐month change (baseline, 8.6 ± 3.6; follow‐up: 10.8 ± 3.6; annualized difference: 3.4 ± 3.4; n = 49; P < 0.0001). Sample sizes required per arm for a two‐arm, 1‐year follow‐up therapeutic trial to detect 50% change in Progressive Supranuclear Palsy Clinical Deficits Scale progression was estimated to be 65 (two‐sided, two‐sample t test). Conclusion The Progressive Supranuclear Palsy Clinical Deficits Scale is a rapidly completed, clinimetrically sound scale for clinical care and research involving PSP. © 2020 International Parkinson and Movement Disorder Society
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185
eISSN: 1531-8257
DOI: 10.1002/mds.27964
Titel-ID: cdi_proquest_miscellaneous_2341622027
Format
–
Schlagworte
Akinesia
,
Balance
,
clinical rating scales
,
Cognitive ability
,
Disease Progression
,
Dysphagia
,
Female
,
Fingers
,
Gait
,
Humans
,
Male
,
Motor Skills
,
Movement disorders
,
outcome measures
,
Paralysis
,
Parkinson's disease
,
Phenotypes
,
power calculation
,
Progressive supranuclear palsy
,
Reproducibility of Results
,
Supranuclear Palsy, Progressive - diagnosis
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