Details

Autor(en) / Beteiligte

• Marks, Florian
• Kim, Jerome H

Titel

Parting the Clouds over Typhoid with a New Conjugate Vaccine

Ist Teil von

• The New England journal of medicine, 2019-12, Vol.381 (23), p.2262-2264

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Electronic Journals Library - Freely accessible e-journals

Beschreibungen/Notizen

• Typhoid fever is caused by fecal–oral transmission of Salmonella enterica serovar Typhi ( S. Typhi). It has been a deadly companion to mankind for centuries, affecting 10.9 million persons and resulting in an estimated 116,800 deaths per year. 1 Although vaccines against typhoid have been available for more than a century and have been shown to be protective, 2,3 the approved vaccines (injectable Vi polysaccharide and oral, live-attenuated Ty21a typhoid vaccines) have not been useful in populations with a high typhoid burden, particularly in young children. 4 To address this shortfall, the Bill and Melinda Gates Foundation, as well as other donors, has supported . . .