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Pd/PC‐Phos‐Catalyzed Enantioselective Intermolecular Denitrogenative Cyclization of Benzotriazoles with Allenes and N‐Allenamides
Ist Teil von
Angewandte Chemie (International ed.), 2019-08, Vol.58 (33), p.11444-11448
Auflage
International ed. in English
Ort / Verlag
Germany: Wiley Subscription Services, Inc
Erscheinungsjahr
2019
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Reported herein is an asymmetric Pd/PC‐Phos‐catalyzed denitrogenative cyclization of benzotriazoles with allenes and N‐allenamides, representing the first example of enantioselective denitrogenative cyclizations of benzotriazoles. A series of optically active 3‐methyleneindolines were obtained in good yields with high ee values. The use of inexpensive and readily available starting materials, high regio‐ and enantioselectivity, a broad substrate scope, mild reaction conditions, no need for base, as well as versatile functionalization of the 3‐methyleneindolines make this approach attractive.
The first example of an enantioselective denitrogenative cyclization of benzotriazoles with allenes and N‐allenamides is enabled using Pd/PC‐Phos catalysis, and provides rapid access to optically active 3‐methyleneindolines in good yields with high ee values. The method features a general substrate scope, high regioselectivity, and mild reaction conditions. Tf=trifluoromethanesulfonyl.