Details

Autor(en) / Beteiligte

• Bjarnadóttir, Elín
• Stokholm, Jakob
• Chawes, Bo
• Thorsen, Jonathan
• Mora‐Jensen, Anna‐Rosa Cecilie
• Deleuran, Maja
• Bønnelykke, Klaus
• Lauritzen, Lotte
• Bisgaard, Hans

Titel

Determinants of neurodevelopment in early childhood – results from the Copenhagen prospective studies on asthma in childhood (COPSAC2010) mother–child cohort

Ist Teil von

• Acta Paediatrica, 2019-09, Vol.108 (9), p.1632-1641

Ort / Verlag

Norway: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Aim The objective of this study was to identify possible pre‐ and postnatal factors influencing neurodevelopment of the young child. Methods We used data from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) mother–child cohort, but excluded those with a neurological diagnosis, born <37 weeks of gestation and birthweights <2500 g, resulting in 650 children analysed. Neurodevelopment was assessed as age of achievement of early milestones, language scores at 1 and 2 years and cognitive score at 2 ½ years of age. Results Neurodevelopmental scores were not associated with breastfeeding, persistent wheeze, eczema and number of sick days (p > 0.05 in all tests). Early age at milestone achievement was associated with male sex (p = 0.05), lower maternal age (p = 0.02), higher gestational age (p < 0.001) and paternity leave (p = 0.01). A higher 1‐year language score was associated with female sex (p = 0.02) and maternal smoking during pregnancy (p = 0.01) and a higher 2‐year language score with female sex (p < 0.001) and being first born (p = 0.01). A higher cognitive score was associated with female sex (p = 0.02). Conclusion Neurodevelopmental scores were unrelated to breastfeeding, persistent wheeze, eczema and number of sick days. Neurodevelopment in early childhood was mostly associated with gender.