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Modifiable risk factors for cognitive impairment in Parkinson's disease: A systematic review and meta‐analysis of prospective cohort studies
Movement disorders, 2019-06, Vol.34 (6), p.876-883
Guo, Yu
Xu, Wei
Liu, Feng‐Tao
Li, Jie‐Qiong
Cao, Xi‐Peng
Tan, Lan
Wang, Jian
Yu, Jin‐Tai
2019
Details
Autor(en) / Beteiligte
Guo, Yu
Xu, Wei
Liu, Feng‐Tao
Li, Jie‐Qiong
Cao, Xi‐Peng
Tan, Lan
Wang, Jian
Yu, Jin‐Tai
Titel
Modifiable risk factors for cognitive impairment in Parkinson's disease: A systematic review and meta‐analysis of prospective cohort studies
Ist Teil von
Movement disorders, 2019-06, Vol.34 (6), p.876-883
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2019
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Background Cognitive impairment is a common and devastating manifestation in Parkinson's disease (PD). We aimed to identify modifiable risk factors for PD with cognitive impairment. Methods We systematically searched PubMed and the Cochrane Library from June 1937 to September 2018 and included prospective cohort studies with random‐effects model used to combine estimates. Primary analyses for all types of cognitive impairments and subgroup analyses for separate outcomes were conducted. Results A total of 31,298 articles were identified, of which 32 articles with 18 factors met the inclusion criteria for meta‐analysis. In the primary analysis, 9 modifiable risk factors were found to increase the risk of PD with cognitive impairment, including postural‐instability‐gait disorder (relative risk = 3.76, 95% confidence interval = 1.36‐10.40), hallucinations (relative risk = 3.09, 95% confidence interval = 1.61‐5.93), orthostatic hypotension (relative risk = 2.98, 95% confidence interval = 1.41‐6.28), cerebrovascular disease (relative risk = 1.52, 95% confidence interval = 1.01‐2.28), diabetes mellitus (relative risk = 1.47, 95% confidence interval = 1.13‐1.92), obesity (relative risk = 1.38, 95% confidence interval = 1.15‐1.65), cardiac disease (relative risk = 1.35, 95% confidence interval = 1.17‐1.56), alcohol consumption (relative risk = 1.32, 95% confidence interval = 1.15‐1.52), and smoking (relative risk = 1.31, 95% confidence interval = 1.14‐1.50). In the subgroup analysis, postural‐instability‐gait disorder subtype, orthostatic hypotension and hallucinations may increase the risk of dementia in PD. A total of 37 articles were included in the systematic review, in which 9 risk factors and 1 protective factor were additionally associated in single studies with the risk of PD with cognitive impairment, and 5 factors were associated with specific cognition domains. Conclusions Effective interventions in the management of PD symptoms, comorbidities, and lifestyles may be promising to reduce PD with cognitive impairment risk. © 2019 International Parkinson and Movement Disorder Society
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185
eISSN: 1531-8257
DOI: 10.1002/mds.27665
Titel-ID: cdi_proquest_miscellaneous_2191359912
Format
–
Schlagworte
Cerebrovascular diseases
,
Cognitive ability
,
Cognitive Dysfunction - etiology
,
cognitive impairment
,
Confidence intervals
,
Coronary artery disease
,
Dementia disorders
,
Diabetes mellitus
,
Gait
,
Gait Disorders, Neurologic - complications
,
Hallucinations
,
Health risk assessment
,
Heart diseases
,
Humans
,
Hypotension
,
meta‐analysis
,
modifiable risk factors
,
Movement disorders
,
Neurodegenerative diseases
,
Obesity - complications
,
Parkinson Disease - complications
,
Parkinson's disease
,
Parkinsons disease
,
Posture
,
Risk Factors
,
Smoking
,
Smoking - adverse effects
,
Systematic review
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