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A review on diverse heterocyclic compounds as the privileged scaffolds in antimalarial drug discovery
Ist Teil von
European journal of medicinal chemistry, 2018-10, Vol.158, p.917-936
Ort / Verlag
France: Elsevier Masson SAS
Erscheinungsjahr
2018
Link zum Volltext
Quelle
ScienceDirect Journals (5 years ago - present)
Beschreibungen/Notizen
The upward extend of malaria collectively with the emergence of resistance against predictable drugs has put enormous pressure on public health systems to introduce new malaria treatments. Heterocycles play an important role in the design and discovery of new malaria active compounds. Heterocyclic compounds have attracted significant attention for malaria treatment because of simplicity of parallelization and the examining power with regard to chemical space. Introduction of a variety of heterocyclic compounds have enabled to maintain the high levels of antimalarial potency observed for other more lipophilic analogues whilst improving the solubility and the oral bioavailability in pre-clinical species. In this review, we present an overview of recent literature to provide imminent into the applications of different heterocyclic scaffolds in fighting against malaria.
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•An overview about the progress of heterocyclic derivatives as antimalarial agent.•The mode of action of various heterocyclic derivatives is discussed.•Review, we present an overview of recent progresses and applications of different heterocyclic scaffolds as potential antimalarials to cover the way for the development of new antimalarials drug.