Details

Autor(en) / Beteiligte

• Srinivasulu, Cheemanapalli
• Ramgopal, Mopuri
• Ramanjaneyulu, Golla
• Anuradha, C.M.
• Suresh Kumar, Chitta

Titel

Syringic acid (SA) ‒ A Review of Its Occurrence, Biosynthesis, Pharmacological and Industrial Importance

Ist Teil von

• Biomedicine & pharmacotherapy, 2018-12, Vol.108, p.547-557

Ort / Verlag

France: Elsevier Masson SAS

Erscheinungsjahr

2018

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• [Display omitted] •Syringic acid (SA) is a phenolic compound of natural origin.•SA is an excellent compound to be used as a therapeutic agent in various diseases (diabetes, CVDs, cancer, cerebral ischemia, neuro and liver damage) and possess anti-oxidant, antimicrobial, anti-inflammatory and antiendotoxic activities.•SA can modulates the dynamics of several biological targets such as proteins, transcriptional factors, growth factors and signaling molecules involved in disease progression.•Therapeutic activity of SA is attributed by the presence of methoxy groups onto the aromatic ring at positions 3 and 5.•SA has greater industrial applications include bioremediation, photocatalytic ozonation, laccase based detoxification. The use of phytochemicals in control of human diseases have been considerable public and scientific interest in current days. Syringic acid (SA), a phenolic compound often found in fruits and vegetables and which is synthesized via shikimic acid pathway in plants. It shows a wide range of therapeutic applications in prevention of diabetes, CVDs, cancer, cerebral ischemia; as well as it possess anti-oxidant, antimicrobial, anti-inflammatory, antiendotoxic, neuro and hepatoprotective activities. It has an effective free radical scavenger and alleviates the oxidative stress markers. The therapeutic property of SA is attributed by the presence of methoxy groups onto the aromatic ring at positions 3 and 5. The strong antioxidant activity of SA may confer its beneficial effects for human health. SA has the potential to modulate enzyme activity, protein dynamics and diverse transcription factors involved in diabetes, inflammation, cancer and angiogenesis. In vivo experimental data and histopathological studies on SA activity has delineated its possible therapeutic mechanisms. Besides usage in biomedical field, SA has greater industrial applications in bioremediation, photocatalytic ozonation, and laccase based catalysis. The present review deals about SA natural sources, biosynthesis, bioavailability, biomedical applications (in vivo and in vito. The review addresses basic information about molecular mechanisms, therapeutic and industrial potential of SA.