Details

Autor(en) / Beteiligte

• Abboud, Martine I
• McAllister, Tom E
• Leung, Ivanhoe K H
• Chowdhury, Rasheduzzaman
• Jorgensen, Christian
• Domene, Carmen
• Mecinović, Jasmin
• Lippl, Kerstin
• Hancock, Rebecca L
• Hopkinson, Richard J
• Kawamura, Akane
• Claridge, Timothy D W
• Schofield, Christopher J

Titel

2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2

Ist Teil von

• Chemical communications (Cambridge, England), 2018, Vol.54 (25), p.3130-3133

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Prolyl hydroxylation of hypoxia inducible factor (HIF)-α, as catalysed by the Fe(ii)/2-oxoglutarate (2OG)-dependent prolyl hydroxylase domain (PHD) enzymes, has a hypoxia sensing role in animals. We report that binding of prolyl-hydroxylated HIF-α to PHD2 is ∼50 fold hindered by prior 2OG binding; thus, when 2OG is limiting, HIF-α degradation might be inhibited by PHD binding.