Details

Autor(en) / Beteiligte

• Saakian, David B

Titel

Kinetics of biochemical sensing by single cells and populations of cells

Ist Teil von

• Physical review. E, 2017-10, Vol.96 (4-1), p.042413-042413, Article 042413

Ort / Verlag

United States

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• We investigate the collective stationary sensing using N communicative cells, which involves surface receptors, diffusive signaling molecules, and cell-cell communication messengers. We restrict the scenarios to the signal-to-noise ratios (SNRs) for both strong communication and extrinsic noise only. We modified a previous model [Bialek and Setayeshgar, Proc. Natl. Acad. Sci. USA 102, 10040 (2005)PNASA60027-842410.1073/pnas.0504321102] to eliminate the singularities in the fluctuation correlations by considering a uniform receptor distribution over the surface of each cell with a finite radius a. The modified model enables a simple and rigorous mathematical treatment of the collective sensing phenomenon. We then derive the scaling of the SNR for both juxtacrine and autocrine cases in all dimensions. For the optimal locations of the cells in the autocrine case, we find identical scaling for both two and three dimensions.