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Internal Peptide Late‐Stage Diversification: Peptide‐Isosteric Triazoles for Primary and Secondary C(sp3)−H Activation
Ist Teil von
Angewandte Chemie (International ed.), 2018-01, Vol.57 (1), p.203-207
Auflage
International ed. in English
Ort / Verlag
Germany: Wiley Subscription Services, Inc
Erscheinungsjahr
2018
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Secondary C(sp3)−H arylations were accomplished by palladium catalysis with triazoles as peptide bond isosteres. The unique power of this approach is highlighted by the possibility of achieving secondary C(sp3)−H functionalizations on terminal peptides as well as the unprecedented positional‐selective C(sp3)−H functionalization of internal peptide positions, setting the stage for modular peptide late‐stage diversification.
Internal Tzl: Secondary C(sp3)−H arylations were accomplished by palladium catalysis with triazole (Tzl) moieties as peptide bond isosteres. This approach can be adopted for C(sp3)−H functionalizations on terminal as well as internal peptide positions with high positional selectivity.