Details

Autor(en) / Beteiligte

• So, Po Lam
• Cheng, Kwun Yue Yvonne
• Cheuk, Kwan Yiu
• Chiu, Wan Kam
• Mak, Shui Lam
• Mok, Sau Lan
• Lo, Tsz Kin
• Yung, Wai Kuen
• Lo, Fai Man
• Chung, Hon Yin Brian
• Kan, Sik Yau Anita
• Lee, Chin Peng
• Tang, Hoi Yin Mary

Titel

Parental decisions following prenatal diagnosis of sex chromosome aneuploidy in Hong Kong

Ist Teil von

• The journal of obstetrics and gynaecology research, 2017-12, Vol.43 (12), p.1821-1829

Ort / Verlag

Australia: Wiley Subscription Services, Inc

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Aim According to the published work, pregnancy termination rates due to prenatal diagnosis of fetal sex chromosome aneuploidies (SCA) vary widely. Some potentially modifiable and non‐modifiable factors have been reported to be associated with parental decision. This study aimed to evaluate the rate of pregnancy termination for fetal SCA and the factors influencing parents' decisions in Hong Kong. Methods This was a 21‐year retrospective cohort study of parents' decisions following prenatal diagnosis of SCA. Univariate and multivariate analyses for the association between demographic factors, prenatal factors, or counseling provided and decision‐making were conducted. Results The study included 399 pregnancies with prenatal diagnosis of SCA and the overall termination rate was 55.6% (91.7%, 48.0%, 23.4%, 4.8%, and 22.7% for 45,X, 47,XXY, 47,XXX, 47,XYY, and mosaicism, respectively). Pregnancies with ultrasound abnormalities were associated with higher termination rates than pregnancies with normal ultrasound findings (91.3% vs 28.3%, P < 0.0001). From multivariate regression analysis on 226 pregnancies with normal ultrasound examination, a higher likelihood to terminate was found in pregnancies affected by 45,X and 47,XXY (adjusted odds ratio, 4.72, P < 0.0001). Increased maternal age and history of infertility were associated with lower likelihood to terminate (adjusted odds ratio, 0.9, P = 0.012; and 5.12, P = 0.038, respectively). The pregnancy termination rate declined over time. Conclusion A significant correlation was found between the termination of SCA‐affected pregnancy and the presence of fetal sonographic abnormalities, type of SCA, maternal age, and presence of infertility.