Details

Autor(en) / Beteiligte

• Singh, Ashok K.
• Raj, Vinit
• Saha, Sudipta

Titel

Indole-fused azepines and analogues as anticancer lead molecules: Privileged findings and future directions

Ist Teil von

• European journal of medicinal chemistry, 2017-12, Vol.142, p.244-265

Ort / Verlag

France: Elsevier Masson SAS

Erscheinungsjahr

2017

Link zum Volltext

Quelle

ScienceDirect Journals (5 years ago - present)

Beschreibungen/Notizen

• The search for new lead compounds of simple structure, displaying highest quality anti-tumor potency with new mechanisms of action and least adverse effects is the major intention of cancer drug discovery now a days. For the time being, indole-fused azepines emerged as a simple class of compounds prolifically designed with strong pharmacological significances in particular of cancer protecting ability. In the recent years from the efforts of our research group, indole-fused heteroazepines, a simple structural class achieved by fusion of indole with oxygen, sulphur and nitrogen containing heteroazepine rings, have known for its superior outcomes in cancer treatment. Surprisingly, the chemistry and biology of these unique families with an amazing role in cancer drug discovery has remained broadly unexplored. This short review is consequently an endeavor to highlight the preliminary ideas over this structural class and to draw the medical attention towards future development of indole-fused azepines and analogues for their promising function in cancer drug discovery. This review outlines the critical aspects of design and structure-activity relationship (SAR) of indole-fused azepines and related ring-fused systems as anticancer agents with important synthetic strategies. [Display omitted] •The review gives insights into the current status of indole-fused azepines and analogues.•The design strategy and SAR are presented in easily understandable graphical manner.•The review also compiles important synthetic strategies of the present structural scaffold.•The review highlights the future needs for the development of this structural scaffold.