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BibTeX
Gelatinized‐core liposomes: Toward a more robust carrier for hydrophilic molecules
Journal of biomedical materials research. Part A, 2017-11, Vol.105 (11), p.3086-3092
Hathout, Rania M.
Gad, Heba A.
Metwally, Abdelkader A.
2017
Details
Autor(en) / Beteiligte
Hathout, Rania M.
Gad, Heba A.
Metwally, Abdelkader A.
Titel
Gelatinized‐core liposomes: Toward a more robust carrier for hydrophilic molecules
Ist Teil von
Journal of biomedical materials research. Part A, 2017-11, Vol.105 (11), p.3086-3092
Ort / Verlag
United States: Wiley Subscription Services, Inc
Erscheinungsjahr
2017
Link zum Volltext
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
The use of liposomes as a delivery system for hydrophobic and hydrophilic drugs is well recognized. However, they possess several limitations that remained unresolved, including stability problems, low entrapment of the hydrophilic drugs, and the subsequent rapid release. This study introduces a novel approach to incorporate gelatin in the liposomal core to overcome these limitations. A rheological study was conducted to select suitable masses of the gelatin used in the liposomal formulations. Moreover, a full‐factorial experimental design was utilized to compare the newly produced gel–core liposomes to the conventional liposomes with respect to the amount of a model hydrophilic molecule loading. An advanced machine learning method, namely, artificial neural networks was utilized to capture the effects of gelatin and cholesterol incorporation in the liposomes on the entrapment efficiency. The results revealed the successful preparation of the novel vesicles and their superiority over the conventional liposomes in drug loading, sustaining the drug release and stability which pose the newly introduced liposomal system as a successful delivery carrier for hydrophilic molecules and drugs. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3086–3092, 2017.
Sprache
Englisch
Identifikatoren
ISSN: 1549-3296
eISSN: 1552-4965
DOI: 10.1002/jbm.a.36175
Titel-ID: cdi_proquest_miscellaneous_1926687103
Format
–
Schlagworte
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
,
Anti-Inflammatory Agents, Non-Steroidal - chemistry
,
Artificial neural networks
,
Cholesterol
,
Cyclooxygenase Inhibitors - administration & dosage
,
Cyclooxygenase Inhibitors - chemistry
,
Drug delivery systems
,
Drug Liberation
,
Drugs
,
Entrapment
,
Experimental design
,
Formulations
,
full‐factorial
,
Gelatin
,
Gelatin - chemistry
,
hydrophilic
,
Hydrophobic and Hydrophilic Interactions
,
Hydrophobicity
,
Learning algorithms
,
Liposomes
,
Liposomes - chemistry
,
Machine learning
,
Neural networks
,
Neural Networks (Computer)
,
Rheological properties
,
Rheology
,
Sodium Salicylate - administration & dosage
,
Sodium Salicylate - chemistry
,
Stability
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