Details

Autor(en) / Beteiligte

• Berg, Johanna
• Zscheppang, Katja
• Fatykhova, Diana
• Tönnies, Mario
• Bauer, Torsten T
• Schneider, Paul
• Neudecker, Jens
• Rückert, Jens C
• Eggeling, Stephan
• Schimek, Maria
• Gruber, Achim D
• Suttorp, Norbert
• Hippenstiel, Stefan
• Hocke, Andreas C

Titel

Tyk2 as a target for immune regulation in human viral/bacterial pneumonia

Ist Teil von

• The European respiratory journal, 2017-07, Vol.50 (1), p.1601953-1601953

Ort / Verlag

England: European Respiratory Society Journals Ltd

Erscheinungsjahr

2017

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• The severity and lethality of influenza A virus (IAV) infections is frequently aggravated by secondary bacterial pneumonia. However, the mechanisms in human lung tissue that provoke this increase in fatality are unknown and therapeutic immune modulatory options are lacking.We established a human lung co-infection model to investigate innate immune related mechanisms contributing to the susceptibility of secondary pneumococcal pneumonia.We revealed that type I and III interferon (IFN) inhibits -induced interleukin (IL)-1β release. The lack of IL-1β resulted in the repression of bacterially induced granulocyte-macrophage colony-stimulating factor (GM-CSF) liberation. Specific inhibition of IFN receptor I and III-associated tyrosine kinase 2 (Tyk2) completely restored the -induced IL-1β-GM-CSF axis, leading to a reduction of bacterial growth. A preceding IAV infection of the human alveolus leads to a type I and III IFN-dependent blockade of the early cytokines IL-1β and GM-CSF, which are key for orchestrating an adequate innate immune response against bacteria. Their virally induced suppression may result in impaired bacterial clearance and alveolar repair.Pharmacological inhibition of Tyk2 might be a new treatment option to sustain beneficial endogenous GM-CSF levels in IAV-associated secondary bacterial pneumonia.