Details

Autor(en) / Beteiligte

• Kim, A Rum
• Kim, Kyung Min
• Byun, Mi Ran
• Hwang, Jun-Ha
• Park, Jung Il
• Oh, Ho Taek
• Kim, Hyo Kyeong
• Jeong, Mi Gyeong
• Hwang, Eun Sook
• Hong, Jeong-Ho

Titel

Catechins activate muscle stem cells by Myf5 induction and stimulate muscle regeneration

Ist Teil von

• Biochemical and biophysical research communications, 2017-07, Vol.489 (2), p.142-148

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Muscle weakness is one of the most common symptoms in aged individuals and increases risk of mortality. Thus, maintenance of muscle mass is important for inhibiting aging. In this study, we investigated the effect of catechins, polyphenol compounds in green tea, on muscle regeneration. We found that (−)-epicatechin gallate (ECG) and (−)-epigallocatechin-3-gallate (EGCG) activate satellite cells by induction of Myf5 transcription factors. For satellite cell activation, Akt kinase was significantly induced after ECG treatment and ECG-induced satellite cell activation was blocked in the presence of Akt inhibitor. ECG also promotes myogenic differentiation through the induction of myogenic markers, including Myogenin and Muscle creatine kinase (MCK), in satellite and C2C12 myoblast cells. Finally, EGCG administration to mice significantly increased muscle fiber size for regeneration. Taken together, the results suggest that catechins stimulate muscle stem cell activation and differentiation for muscle regeneration. •Catechins stimulate muscle regeneration after muscle damage.•Catechins activate muscle satellite cells through Akt activation and Myf5 induction.•Catechins stimulate myogenesis through the induction of Myogenin and MCK.