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The influence of positive selection and trans-species evolution on DPB diversity in the golden snub-nosed monkeys (Rhinopithecus roxellana)
Ist Teil von
Primates, 2016-10, Vol.57 (4), p.489-499
Ort / Verlag
Tokyo: Springer Japan
Erscheinungsjahr
2016
Quelle
MEDLINE
Beschreibungen/Notizen
Genetic variation plays a significant role in the adaptive potential of the endangered species. The variation at major histocompatibility complex (MHC) genes can offer valuable information on selective pressure related to natural selection and environmental adaptation, particularly the ability of a host to continuously resist evolving parasites. Thus, the genetic polymorphism on exon 2 of the MHC
DPB1
gene in the golden snub-nosed monkeys (
Rhinopithecus roxellana
) was specifically analyzed. The results show that the 6
Rhro
-
DPB1
alleles identified from 87 individuals exhibit positive selection and trans-species polymorphism. The results also imply that although the populations of the species have experienced dramatic reduction and severe habitat fragmentation in recent Chinese history, balancing selection still maintains relatively consistent, with moderate
DPB1
polymorphism. Thus, the study provides valuable information and evidence in developing effective strategies and tactics for genetic health and population size expansion of the species. It also offers strong genetic background for further studies on other primate species, particularly those in
Rhinopithecus
—a further endeavor that would result in fully understanding the MHC genetic information of the Asian colobines.