Details

Autor(en) / Beteiligte

• Das, Sayantani
• Liu, Luping
• Zheng, Yiying
• Alachraf, M. Wasim
• Thiel, Walter
• De, Chandra Kanta
• List, Benjamin

Titel

Nitrated Confined Imidodiphosphates Enable a Catalytic Asymmetric Oxa-Pictet–Spengler Reaction

Ist Teil von

• Journal of the American Chemical Society, 2016-08, Vol.138 (30), p.9429-9432

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The development of a highly enantioselective catalytic oxa-Pictet–Spengler reaction has proven a great challenge for chemical synthesis. We now report the first example of such a process, which was realized by utilizing a nitrated confined imidodiphosphoric acid catalyst. Our approach provides substituted isochroman derivatives from both aliphatic and aromatic aldehydes with high yields and excellent enantioselectivities. DFT calculations provide insight into the reaction mechanism.