Details

Autor(en) / Beteiligte

• Turan, Ilke Simsek
• Cakmak, Fatma Pir
• Yildirim, Deniz Cansen
• Cetin-Atalay, Rengul
• Akkaya, Engin U.

Titel

Near-IR Absorbing BODIPY Derivatives as Glutathione-Activated Photosensitizers for Selective Photodynamic Action

Ist Teil von

• Chemistry : a European journal, 2014-12, Vol.20 (49), p.16088-16092

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• Enhanced spatiotemporal selectivity in photonic sensitization of dissolved molecular oxygen is an important target for improving the potential and the practical applications of photodynamic therapy. Considering the high intracellular glutathione concentrations within cancer cells, a series of BODIPY‐based sensitizers that can generate cytotoxic singlet oxygen only after glutathione‐mediated cleavage of the electron‐sink module were designed and synthesized. Cell culture studies not only validate our design, but also suggest an additional role for the relatively hydrophobic quencher module in the internalization of the photosensitizer. Power with a control switch: Enhanced spatiotemporal selectivity in photonic sensitization of dissolved molecular oxygen is an important target for improving the potential and practice of photodynamic therapy. Considering the high glutathione (GSH) concentrations in cancer cells, a series of BODIPY‐based “caged” sensitizers have been designed and synthesized. The sensitizers can generate cytotoxic singlet oxygen only after glutathione‐mediated cleavage of the electron‐sink module.