Details

Autor(en) / Beteiligte

• Moon, J. H.
• Kim, K. M.
• Choi, S. H.
• Lim, S.
• Park, K. S.
• Kim, Ki Woong
• Jang, Hak Chul

Titel

Sarcopenia as a predictor of future cognitive impairment in older adults

Ist Teil von

• The Journal of nutrition, health & aging, 2016-05, Vol.20 (5), p.496-502

Ort / Verlag

Paris: Springer Paris

Erscheinungsjahr

2016

Link zum Volltext

Quelle

SpringerNature Journals

Beschreibungen/Notizen

• Objectives We investigated the association between the indices of sarcopenia and future risk of cognitive impairment in older adults. Design Community-based prospective cohort study. Setting Community. Participants A total of 297 participants aged ≥65 years without cognitive impairment at baseline (mean age, 71.9 ± 6.6 years; men:women, 158:139) and who underwent cognitive evaluation at the 5-year follow-up. Measurements Sarcopenia parameters including appendicular lean mass (ALM), handgrip strength, and the Short Physical Performance Battery (SPPB) score at baseline were compared according to the later progression of mild cognitive impairment (MCI) and/or dementia. The operational criteria suggested by the Foundation for the National Institutes of Health Sarcopenia Project were used. We performed multivariate logistic regression analysis to identify the independent indicators of the progression of cognitive impairment. Results Among the 297 participants, 242 (81.5%) remained cognitively normal (nonprogression group), whereas 55 (18.5%) showed progression of cognitive impairment (50 subjects (16.8%) to MCI and 5 subjects (1.7%) to dementia) (progression group). Compared with the nonprogression group, subjects in the progression group were older, had a lower educational level, and had lower physical function as assessed by the SPPB; a higher percentage were depressed. Other baseline markers of sarcopenia, including the ALM-to-body mass index ratio and handgrip strength did not differ significantly between the groups. The association between a low SPPB score (<9) and progression of cognitive impairment was maintained after adjustment for conventional risk factors for cognitive impairment (hazard ratio 2.222, 95% confidence interval 1.047–4.716, P = 0.038). Conclusion Decreased physical performance, as assessed by the SPPB, but not other markers of sarcopenia, was independently associated with the risk of later cognitive impairment in older adults.