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Autor(en) / Beteiligte

Titel

GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer’s disease

Ist Teil von

Ort / Verlag

Netherlands: Elsevier Inc

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

Highlights • The microglial receptor GPR84 promotes microgliosis in APP/PS1 mice, a model of Alzheimer’s disease. • Without GPR84, APP/PS1 mice show more dendritic degeneration and accelerated cognitive decline. • GPR84 (and therefore microglia) plays a modest, but beneficial role in amyloid pathology. • This study reveals for the first time a role of GPR84 in vivo.

Sprache: Englisch
Identifikatoren: ISSN: 0889-1591
eISSN: 1090-2139
DOI: 10.1016/j.bbi.2015.01.010
Titel-ID: cdi_proquest_miscellaneous_1732816887

Format: –
Schlagworte: Allergy and Immunology, Alzheimer Disease - genetics, Alzheimer Disease - metabolism, Alzheimer Disease - pathology, Amyloid beta-Peptides - metabolism, Animals, Chemotaxis, Cognition Disorders - genetics, Cognition Disorders - metabolism, Cognition Disorders - pathology, Dendrites - metabolism, Dendrites - pathology, Disease Models, Animal, Endotoxemia, G-protein coupled receptor 84, Gliosis - genetics, Gliosis - metabolism, Gliosis - pathology, Hippocampus - metabolism, Hippocampus - pathology, Lipopolysaccharide, Mice, Mice, Knockout, Mice, Transgenic, Microglia - metabolism, Microglia - pathology, Microglial cells, Multiple sclerosis, Nerve Degeneration - genetics, Nerve Degeneration - metabolism, Nerve Degeneration - pathology, Neurodegeneration, Neuroinflammation, Psychiatry, Receptors, G-Protein-Coupled - genetics, Receptors, G-Protein-Coupled - metabolism, Up-Regulation, β-Amyloid

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