Details

Autor(en) / Beteiligte

• Falabregues, Amélie
• Daul, Marion
• Pourroy, Bertrand
• Gauthier-Villano, Laurence
• Pisano, Pascale
• Rathelot, Pascal
• Vialettes, Bernard

Titel

Pertinence of Off-label Prescriptions of Innovating and Expensive Drugs in a University Hospital

Ist Teil von

• Therapie, 2015-09, Vol.70 (5), p.385-402

Ort / Verlag

France

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Pertinence of off-label prescriptions of innovative and expensive drugs needs a strict scientific appraisal to prevent adverse reaction risks and financial drift. Pertinence of such prescriptions has been analyzed in a University Hospital by bibliometric methods. Scientific publications issued from this clinical activity have been also evaluated. Oncology differed from other clinical specialties by a better pertinence in justifying off-label prescriptions (good evidence level in 46% vs. 21%, scientific publications issued from A/B ranked journals: 51% versus 41%). Quality of scientific production from oncologists was also better (publication impact factor [IF] mean: 4.571 versus 2.245). The better pertinence of off-label prescriptions by oncologists in comparison to others clinicians' ones was mainly due to a shorter field of indications but also to a more efficient organisation such as systematic prescription by seniors, dedicated computerized provider order entry, multidisciplinary team meetings and collaborative culture.