Details

Autor(en) / Beteiligte

• Gathogo, Esther N
• Hamzah, Lisa
• Hilton, Rachel
• Marshall, Neal
• Ashley, Caroline
• Harber, Mark
• Levy, Jeremy B
• Jones, Rachael
• Boffito, Marta
• Khoo, Saye H
• Drage, Martin
• Bhagani, Sanjay
• Post, Frank A

Titel

Kidney transplantation in HIV-positive adults: the UK experience

Ist Teil von

• International journal of STD & AIDS, 2014-01, Vol.25 (1), p.57-66

Ort / Verlag

London, England: SAGE Publications

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• HIV-positive patients are at increased risk of end-stage kidney disease (ESKD). Kidney transplantation (KT) is an established treatment modality for ESKD in the general population. Recent data have confirmed the feasibility of kidney transplantation in HIV-positive patients, and kidney transplantation is increasingly offered to ESKD patients with well-controlled HIV infection. We report clinical outcomes in a national cohort study of kidney transplantation in HIV-positive patients. In all, 35 HIV-positive KT recipients who had undergone KT up to December 2010 (66% male, 74% black ethnicity) were identified; the median CD4 cell count was 366, all had undetectable HIV RNA levels at kidney transplantation, and 44% received a kidney from a live donor. Patient survival at 1 and 3 years was 91.3%, and graft survival 91.3% and 84.7%, respectively. At one-year post-kidney transplantation, the cumulative incidence of acute rejection was 48%, and the median (IQR) eGFR was 64 (46, 78) mL/min/1.73 m2. Although HIV viraemia and HIV disease progression were uncommon, renal complications were relatively frequent. Our study corroborates the feasibility of kidney transplantation in HIV-positive patients. The high rates of acute rejection suggest that the optimal immune suppression strategy in this population remains to be refined.