Details

Autor(en) / Beteiligte

• Edwards, Martin O., BM, MRCPCH
• Kotecha, Sarah J., BSc, SRD
• Lowe, John, BSc
• Richards, Louise, MSc
• Watkins, W. John, PhD
• Kotecha, Sailesh, PhD, FRCPCH

Titel

Early-term birth is a risk factor for wheezing in childhood: A cross-sectional population study

Ist Teil von

• Journal of allergy and clinical immunology, 2015-09, Vol.136 (3), p.581-587.e2

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Background Early term–born (37-38 weeks' gestation) infants have increased respiratory morbidity during the neonatal period compared with full term–born (39-42 weeks' gestation) infants, but longer-term respiratory morbidity remains unclear. Objective We assessed whether early term–born children have greater respiratory symptoms and health care use in childhood compared with full term–born children. Methods We surveyed 1- to 10-year-old term-born children (n = 13,361). Questionnaires assessed respiratory outcomes with additional data gathered from national health databases. Results Of 2,845 eligible participants, 545 were early term–born and 2,300 were full term–born. Early term–born children had higher rates of admission to the neonatal unit (odds ratio [OR], 1.7; 95% CI, 1.2-2.5) and admission to the hospital during their first year of life (OR, 1.6; 95% CI, 1.2-2.1). Forty-eight percent of early term–born children less than 5 years old reported wheeze ever compared with 39% of full term–born children (OR, 1.5; 95% CI, 1.1-1.9), and 26% versus 17% reported recent wheezing (OR, 1.7; 95% CI, 1.3-2.4). Early term–born children older than 5 years reported higher rates of wheeze ever (OR, 1.4; 95% CI, 1.05-1.8) and recent wheezing over the last 12 months than full-term control subjects (OR, 1.4; 95% CI, 1.02-2.0). Increased rates of respiratory symptoms in early term–born children persisted when family history of atopy and delivery by means of cesarean sections were included in logistic regression models. Conclusion Early term–born children had significantly increased respiratory morbidity and use of health care services when compared with full term–born children, even when stratified by mode of delivery and family history of atopy.