Details

Autor(en) / Beteiligte

• Okada, Yukinori
• Momozawa, Yukihide
• Ashikawa, Kyota
• Kanai, Masahiro
• Matsuda, Koichi
• Kamatani, Yoichiro
• Takahashi, Atsushi
• Kubo, Michiaki

Titel

Construction of a population-specific HLA imputation reference panel and its application to Graves' disease risk in Japanese

Ist Teil von

• Nature genetics, 2015-07, Vol.47 (7), p.798-802

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2015

Link zum Volltext

Beschreibungen/Notizen

• To fine map association signals of human leukocyte antigen (HLA) variants in the major histocompatibility complex (MHC) region, we constructed a Japanese population-specific reference panel (n = 908). We conducted trans-ancestry comparisons of linkage disequilibrium (LD) and haplotype structure for HLA variants using an entropy-based LD measurement, ɛ, and a visualization tool to capture high-dimensional variables. Our Japanese reference panel exhibited stronger LD between HLA genes than European or other East Asian populations, characterized by one population-specific common long-range HLA haplotype. We applied HLA imputation to genome-wide association study (GWAS) data for Graves' disease in Japanese (n = 9,003) and found that amino acid polymorphisms of multiple class I and class II HLA genes independently contribute to disease risk (HLA-DPB1, HLA-A, HLA-B and HLA-DRB1; P < 2.3 × 10(-6)), with the strongest impact at HLA-DPB1 (P = 1.6 × 10(-42)). Our study illustrates the value of population-specific HLA reference panels.