Details

Autor(en) / Beteiligte

• Gao, Shuai
• Huan, Shu-Ling
• Han, Li-Yan
• Li, Feng
• Ji, Xiang-Fen
• Li, Xin-You
• Fan, Yu-Chen
• Wang, Kai

Titel

Overexpression of serum sST2 is associated with poor prognosis in acute-on-chronic hepatitis B liver failure

Ist Teil von

• Clinics and research in hepatology and gastroenterology, 2015-06, Vol.39 (3), p.315-323

Ort / Verlag

France

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Summary Background and objective Interleukin-33 (IL-33) and soluble ST2 (sST2) have been demonstrated to be involved in liver injury. The present study aims to evaluate serum IL-33 and sST2 level in acute-on-chronic hepatitis B liver failure (ACHBLF) and determine their predictive value for prognosis. Methods Serum IL-33 and sST2 level in patients with ACHBLF, chronic hepatitis B (CHB) and healthy controls (HCs) were determined by enzyme-linked immunosorbent assay (ELISA). Clinical and laboratory parameters were obtained. Results Serum IL-33 was significantly higher in patients with ACHBLF (313.10 ± 419.97 pg/ml) than those with CHB (97.25 ± 174.67 pg/ml, P < 0.01) and HCs (28.39 ± 6.53 pg/ml, P < 0.01). Serum sST2 was significantly higher in patients with ACHBLF (1545.87 ± 1135.70 pg/ml) than those with CHB (152.55 ± 93.28 pg/ml, P < 0.01) and HCs (149.27 ± 104.90 pg/ml, P < 0.01). In all participants, serum IL-33 was significantly correlated with sST2 ( r = 0.43, P < 0.01). In patients with ACHBLF, serum IL-33 was significantly correlated with alanine aminotransferase (ALT; r = 0.26, P = 0.04). Serum sST2 was significantly correlated with total bilirubin (TBIL; r = 0.59, P < 0.01), Log10 [HBV DNA] ( r = −0.47, P < 0.01) and model for end-stage liver diseases (MELD; r = 0.28, P = 0.03). Serum sST2 had an area under the receiver operating characteristic curve (AUC) of 0.81 in predicting 3-month mortality of ACHBLF. Patients with ACHBLF who had sST2 >1507 pg/ml showed significantly poorer survival than those who had sST2 ≤1507 pg/ml ( P < 0.01). Moreover, measurement of sST2 and MELD together significantly improved the diagnostic value of MELD alone ( P < 0.05). Conclusions Our study showed that serum IL-33 and sST2 were overexpressed in ACHBLF and sST2 might potentially serve as a prognostic marker for it.