Details

Autor(en) / Beteiligte

• Hengerics Szabó, Alexandra
• Podolec, Peter
• Ferenczy, Viktória
• Kubinec, Róbert
• Blaško, Jaroslav
• Soják, Ladislav
• Górová, Renáta
• Addová, Gabriela
• Ostrovský, Ivan
• Višňovský, Jozef
• Bierhanzl, Václav
• Čabala, Radomír
• Amann, Anton

Titel

The analysis of linear and monomethylalkanes in exhaled breath samples by GC×GC-FID and GC–MS/MS

Ist Teil von

• Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2015-01, Vol.978-979, p.62-69

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• •INCAT device for sampling of hydrocarbons with wide range of volatility was developed.•Comparison of GC×GC-FID and GC–MS/MS methods for exhaled breath analysis was performed.•Determination of all C6C19n-alkanes and C9C19 monomethylalkanes in exhaled breath was performed. A new arrangement of the INCAT (inside needle capillary adsorption trap) device with Carbopack X and Carboxen 1000 as sorbent materials was applied for sampling, preconcentration and injection of C6C19n-alkanes and their monomethyl analogs in exhaled breath samples. For the analysis both GC–MS/MS and GC×GC-FID techniques were used. Identification of the analytes was based on standards, measured retention indices and selective SRM transitions of the individual isomers. The GC–MS/MS detection limits were in the range from 2.1pg for n-tetradecane to 86pg for 5-methyloctadecane. The GC×GC-FID detection limits ranged from 19pg for n-dodecane to 110pg for 3-methyloctane.