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Gallic Acid Regulates Skin Photoaging in UVB‐exposed Fibroblast and Hairless Mice
Phytotherapy research, 2014-12, Vol.28 (12), p.1778-1788
Hwang, Eunson
Park, Sang‐Yong
Lee, Hyun Ji
Lee, Tae Youp
Sun, Zheng‐wang
Yi, Tae Hoo
2014
Details
Autor(en) / Beteiligte
Hwang, Eunson
Park, Sang‐Yong
Lee, Hyun Ji
Lee, Tae Youp
Sun, Zheng‐wang
Yi, Tae Hoo
Titel
Gallic Acid Regulates Skin Photoaging in UVB‐exposed Fibroblast and Hairless Mice
Ist Teil von
Phytotherapy research, 2014-12, Vol.28 (12), p.1778-1788
Ort / Verlag
England: Heyden & Son
Erscheinungsjahr
2014
Link zum Volltext
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Ultraviolet (UV) radiation is the primary factor in skin photoaging, which is characterized by wrinkle formation, dryness, and thickening. The mechanisms underlying skin photoaging are closely associated with degradation of collagen via upregulation of matrix metalloproteinase (MMP) activity, which is induced by reactive oxygen species (ROS) production. Gallic acid (GA), a phenolic compound, possesses a variety of biological activities including antioxidant and antiinflammatory activities. We investigated the protective effects of GA against photoaging caused by UVB irradiation using normal human dermal fibroblasts (NHDFs) in vitro and hairless mice in vivo. The production levels of ROS, interlukin‐6, and MMP‐1 were significantly suppressed, and type I procollagen expression was stimulated in UVB‐irradiated and GA‐treated NHDFs. GA treatment inhibited the activity of transcription factor activation protein 1. The effects of GA following topical application and dietary administration were examined by measuring wrinkle formation, histological modification, protein expression, and physiological changes such as stratum corneum hydration, transepidermal water loss, and erythema index. We found that GA decreased dryness, skin thickness, and wrinkle formation via negative modulation of MMP‐1 secretion and positive regulation of elastin, type I procollagen, and transforming growth factor‐β1. Our data indicate that GA is a potential candidate for the prevention of UVB‐induced premature skin aging. Copyright © 2014 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0951-418X
eISSN: 1099-1573
DOI: 10.1002/ptr.5198
Titel-ID: cdi_proquest_miscellaneous_1635005194
Format
–
Schlagworte
Animals
,
anti-inflammatory activity
,
antioxidants
,
Antioxidants - pharmacology
,
Cells, Cultured
,
collagen
,
Collagen Type I - metabolism
,
elastin
,
erythema
,
fibroblasts
,
Fibroblasts - drug effects
,
Fibroblasts - radiation effects
,
gallic acid
,
Gallic Acid - pharmacology
,
hairless mice
,
Humans
,
Interleukin-6 - metabolism
,
irradiation
,
Male
,
Matrix Metalloproteinase 1 - metabolism
,
metalloproteinases
,
Mice
,
Mice, Hairless
,
MMP-1
,
photoaging
,
protective effect
,
protein synthesis
,
reactive oxygen species
,
Reactive Oxygen Species - metabolism
,
ROS
,
secretion
,
Skin - drug effects
,
Skin - radiation effects
,
Skin Aging - drug effects
,
Skin Aging - radiation effects
,
topical application
,
transcription factors
,
Transforming Growth Factor beta1 - metabolism
,
type I procollagen
,
Ultraviolet Rays
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