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Comprehensive assessment of prognostic markers for sinonasal squamous cell carcinoma
Head & neck, 2014-08, Vol.36 (8), p.1094-1102
Takahashi, Yoko
Bell, Diana
Agarwal, Garima
Roberts, Dianna
Xie, Tong-Xin
El-Naggar, Adel
Myers, Jeffrey N.
Hanna, Ehab Y.
2014
Details
Autor(en) / Beteiligte
Takahashi, Yoko
Bell, Diana
Agarwal, Garima
Roberts, Dianna
Xie, Tong-Xin
El-Naggar, Adel
Myers, Jeffrey N.
Hanna, Ehab Y.
Titel
Comprehensive assessment of prognostic markers for sinonasal squamous cell carcinoma
Ist Teil von
Head & neck, 2014-08, Vol.36 (8), p.1094-1102
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2014
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
ABSTRACT Background Little is known about the molecular signature of the rare tumor sinonasal squamous cell carcinoma (SNSCC). The purpose of this study was to comprehensively assess various molecular biomarkers in SNSCC. Methods We chose 13 markers for this study, which have been known as prognostic markers in head and neck squamous cell carcinoma. Expression of these markers was examined by either in situ hybridization or immunohistochemical methods on tissue microarrays made from 70 SNSCC specimens and 28 matched‐pair normal tissues from patients who underwent surgical resection at our institution. Expression data were correlated with patient clinicopathologic parameters and survival. Results Of the 13 markers, only epidermal growth factor receptor (EGFR) protein expression was associated with significantly shorter disease‐free survival (DFS; p = .01307). EGFR expression was also associated with shorter overall survival (OS), but the difference was not statistically significant. Conclusion Targeted inhibition of tumor EGFR expression may be a new approach to treating SNSCC. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1094–1102, 2014
Sprache
Englisch
Identifikatoren
ISSN: 1043-3074
eISSN: 1097-0347
DOI: 10.1002/hed.23423
Titel-ID: cdi_proquest_miscellaneous_1547532098
Format
–
Schlagworte
Adolescent
,
Adult
,
Aged
,
Aged, 80 and over
,
Biomarkers, Tumor - metabolism
,
Carcinoma, Squamous Cell - metabolism
,
Carcinoma, Squamous Cell - mortality
,
Disease-Free Survival
,
epidermal growth factor receptor
,
Female
,
Humans
,
Immunohistochemistry
,
Male
,
Middle Aged
,
Paranasal Sinus Neoplasms - metabolism
,
Paranasal Sinus Neoplasms - mortality
,
Prognosis
,
prognostic markers
,
Receptor, Epidermal Growth Factor - metabolism
,
Retrospective Studies
,
sinonasal squamous cell carcinoma
,
Survival Analysis
,
Tissue Array Analysis
,
tissue microarrays
,
Young Adult
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