Details

Autor(en) / Beteiligte

• Zhang, Shuai
• Zheng, Lingli
• Dong, Deshi
• Xu, Lina
• Yin, Lianhong
• Qi, Yan
• Han, Xu
• Lin, Yuan
• Liu, Kexin
• Peng, Jinyong

Titel

Effects of flavonoids from Rosa laevigata Michx fruit against high-fat diet-induced non-alcoholic fatty liver disease in rats

Ist Teil von

• Food chemistry, 2013-12, Vol.141 (3), p.2108-2116

Ort / Verlag

Kidlington: Elsevier Ltd

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• •The TFs showed excellent effect against NAFLD in rats.•The TFs inhibited hepatic lipid accumulation.•The TFs prevented mitochondrial membrane potential dysfunctions and ultrastructural alterations.•The TFs regulated fatty acid synthesis and promoted fatty acid β-oxidation.•The TFs did not affect cholesterol synthesis. The effects and mechanisms of the total flavonoids (TFs) from Rosa laevigata Michx fruit on high-fat diet-induced non-alcoholic fatty liver disease (NAFLD) were investigated in this study. Gavage administration of the TFs significantly decreased the relative liver weight, serum AST and ALT activities, the levels of serum lipid, LDL, blood glucose and insulin, suppressed lipid accumulation in liver, and increased serum HDL level. Moreover, the natural product significantly enhanced SOD activity, increased GSH-Px and GSH contents and decreased the concentration of MDA and CYP2E1 expression as well as prevented mitochondrial membrane potential dysfunctions and ultrastructural alterations. Further mechanism investigation indicated that the TFs inhibited hepatic lipid accumulation by suppressing the expressions of some key molecules in fatty acid synthesis pathway and promoting fatty acid β-oxidation, while not by inhibiting cholesterol synthesis. On the base of these, the TFs should be developed as a new drug for treatment of NAFLD.