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Practicability of nitrogen multiple-breath washout measurements in a pediatric cystic fibrosis outpatient setting
Pediatric pulmonology, 2013-08, Vol.48 (8), p.739-746
Singer, Florian
Kieninger, Elisabeth
Abbas, Chiara
Yammine, Sophie
Fuchs, Oliver
Proietti, Elena
Regamey, Nicolas
Casaulta, Carmen
Frey, Urs
Latzin, Philipp
2013
Details
Autor(en) / Beteiligte
Singer, Florian
Kieninger, Elisabeth
Abbas, Chiara
Yammine, Sophie
Fuchs, Oliver
Proietti, Elena
Regamey, Nicolas
Casaulta, Carmen
Frey, Urs
Latzin, Philipp
Titel
Practicability of nitrogen multiple-breath washout measurements in a pediatric cystic fibrosis outpatient setting
Ist Teil von
Pediatric pulmonology, 2013-08, Vol.48 (8), p.739-746
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2013
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Background Although lung clearance index (LCI) is a sensitive indicator of mild cystic fibrosis (CF) lung disease, it is rarely measured due to lengthy protocols and the commercial unavailability of multiple‐breath washout (MBW) setups and tracer gases. We used a newly validated, commercially available nitrogen (N2) MBW setup to assess success rate, duration, and variability of LCI within a 20 min timeframe, during clinical routine. We also evaluated the relationship between LCI and other clinical markers of CF lung disease. Methods One hundred thirty six children (83 with CF) between 4 and 16 years were studied in a pediatric CF outpatient setting. One hundred eighteen out of 136 children were naïve to MBW. Within 20 min, each child was trained, N2MBW was performed, and LCI was analyzed. We assessed intra‐ and between‐test reproducibility in a subgroup of children. Results At least one LCI was feasible in 123 (90%) children, with a mean (range) of 3.3 (1.2–6.4) min per test. Two or more measurements were feasible in 56 (41%) children. Comparing LCI in CF versus controls, LCI mean (SD) was 12.0 (3.9) versus 6.1 (0.9), and the intra‐ and inter‐test coefficient of repeatability was 1.00 versus 0.81 and 0.96 versus 0.62, respectively. LCI was correlated with spirometry, blood gases, and Pseudomonas aeruginosa infection. Conclusions Using available N2MBW equipment, LCI measurements are practical and fast in children. LCI is correlated with markers of CF lung disease. Longer timeframes would be required for triplicate N2MBW tests in inexperienced children. Pediatr Pulmonol. 2013; 48:739–746. © 2012 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 8755-6863
eISSN: 1099-0496
DOI: 10.1002/ppul.22651
Titel-ID: cdi_proquest_miscellaneous_1411632692
Format
–
Schlagworte
Administration, Inhalation
,
Adolescent
,
Breath Tests - methods
,
Child
,
Child, Preschool
,
children
,
cystic fibrosis
,
Cystic Fibrosis - diagnosis
,
Cystic Fibrosis - metabolism
,
Cystic Fibrosis - physiopathology
,
efficiency
,
Female
,
Follow-Up Studies
,
Forced Expiratory Flow Rates
,
Humans
,
Male
,
Nitrogen - administration & dosage
,
Nitrogen - pharmacokinetics
,
Outpatients
,
Prognosis
,
Prospective Studies
,
reproducibility
,
Reproducibility of Results
,
respiratory function test
,
Severity of Illness Index
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